Walter Dixon

Assoc Vice-President/Research

Phone: 780-492-3579
Email: walter.dixon@ualberta.ca
Department: Agricultural, Food & Nutritional Science
Office: 2-51R South Academic Building
Office Hours: By appointment
Address: University of Alberta
2-51R South Academic Building
Edmonton, AB
Canada T6G 2G7

Degree
PhD, University of Cambridge

Job/Research Area 

Molecular Biology, and Member of AVRI Council 

Major Responsibilities/Research Interests 

Research interests focus on gene expression as it relates to several fundamental cell biological processes including cell adhesion, and protein metabolism and secretion. In particular, current research involves the study of a family of four-pass membrane proteins implicated in a variety of cellular processes including adhesion and motility, platelet activation, growth factor signalling and cell proliferation. Members of this protein family are being studied in several normal and transformed eukaryotic cell systems. These studies utilize many recently developed techniques in protein biochemistry and molecular biology including cDNA cloning and expression, antibody screening of cDNA libraries, polymerase chain reaction (PCR) analysis and DNA sequencing. An understanding of the critical factors regulating these essential biological processes will have direct application to a variety of important issues in animal science including fertilization, embryo implantation and development, parasite infection and lactation. 

Graduate Career Opportunities 

Selected Publications 

Martins, K.J., Maclean, I., Murdoch, G.K., W.T. Dixon, and Putman, C.T. (2011) Nitric oxide synthase inhibition delays low-frequency stimulation-induced satellite cell activation in rat fast-twitch muscle. Appl. Physiol. Nutr. Metab. 36(6): 996-1000. 

 

Oliver, G., Novak, S., Patterson, J.L., Pasternak, J.A., Paradis, F., Norrby, M., Oxtoby, K., Dyck, M.K., W.T. Dixon and Foxcroft, G.R. (2011) Restricted feed intake in lactating primiparous sows. II. Effects on subsequent litter sex ratio and embryonic gene expression. Reprod. Fertil. Develop. 23: 899-911.

 

Pink, D.B., Gatrell, S.K., Elango, R., Turchinsky, J., Kiess, A.S. Blemings, K.P., W.T. Dixon, and Ball, R.O. (2011) Lysine alpha-ketoglutarate reductase, but not saccharopine dehydrogenase, is subject to substrate inhibition in pig liver. Nutr. Res.31: 544-554.

 

Dyck, M.K., Foxcroft, G.R., Novak, S., Ruiz-Sanchez, A., Patterson, J. and W.T. Dixon (2011) Biological markers of boar fertility. Reprod. Domest. Anim. 46(2): 55-58.

Gilchrist, A.J., R. Meuser, J. Turchinsky, A.R.E. Shaw, M. Pasdar, and W.T. Dixon. 2002. "Cell adhesion-mediated transformation of a human SCLC cell line is associated with the development of a normal phenotype." Exp. Cell Res. 276:63-78. 

Drozdowski, L.A., W.T. Dixon, A.B.R. Thomson, and M.I. McBurney. 2002. "Short chain fatty acids and total parenteral nutrition affect intestinal gene expression." J. of Parenteral and Enteral Nutrition (JPEN) 26:145-150. 

Novak, S, B.K., F.R. Treacy, C.L. Almeida, J. Mao, W.C. Buhi, W.T. Dixon, and G.R. Foxcroft. 2002. "Regulation of IGF-1 and porcine oviductal protein (pOSP) secretion into the pig oviduct in the peri-ovulatory period, and effects of previous nutrition." Reprod. Nutr. Dev. 42:1-18. 

Alexander, T.W., R. Sharma, E.K. Okine, W.T. Dixon, R.J. Forster, K. Stanford, and T.A. McAllister. 2002. "FEMS." Microbiol. Lett. 10. 214(2):263-269. 

Nakano, T., W.T. Dixon, and L. Ozimek. 2002. "Proteoglycans (Glycosaminoglycans/Mucopolysaccharides)." In: Polysaccharides II. Polysaccharides from Eukaryotes. Biopolymers 6 (16):575-604 (edit. By De Baets, A., Vandamme, E. and Steinbuchel, A.) Wiley-Interscience.. 

Der, J.E., W.T. Dixon, and K. Jimbow. 1993. "A murine monoclonal antibody, MoAb HMSA-5, against a melanosomal component highly expressed in early melanosome developmental stages, and common to normal and neoplastic melanocytes." Brit. J. Cancer 67:47-57. 

Demetrick, D.J., D. Herlyn, M. Tretiak, D. Creasy, H. Clevers, C.J.G.M. Vennegoor, W.T. Dixon, and L.M. Jerry. 1992. "The ME491 melanoma-associated glycoprotein family. Antigenic identity of the ME491, NKI/C-3, NGA and CD63 proteins." J. Natl. Cancer Institute 84:422-429. 

W.T. Dixon, D.J. Demetrick, K. Ohyama, L.K.J. Sikora, and L.M. Jerry. 1990. "Biosynthesis, glycosylation and intracellular processing of the neuroglandular antigen, a human melanoma-associated antigen." Cancer Research 50:4557-4565.